Eva Vertes looks to the future of medicine

Eva Vertes isn't a normal young person. At least, that's what our culture would tell us. Her discovery, at age 17, of a compound that inhibits brain cell death was regarded as a step toward curing Alzheimer's and won her Best in Medicine at the International Science Fair. Quickly labeled a microbiology prodigy, Eva now aims to find better ways to treat — and avoid — cancer.

Scientists Discover Mice's Hearts Can Heal Themselves, Are Other Mammals Next?

New research published online today in the journalScience found that newborn mice can regenerate working heart tissue.

So what's the big whoop? Scientists already knew that certain amphibians and fish could regenerate cardiac tissue.

Well that, it turns out, is what inspired researchers at the Southwestern Medical Center in Texas to consider the possibility that mammalian hearts could also regenerate. Given the similarities in the hearts of adult zebrafish -- which can regrow tissue -- and immature mammals, researchers wondered if they couldn't "conserve," as they put it, the same mechanisms of regeneration in mice.

The results? Within 21 days of scientists surgically removing a portion of the left ventricular apex from newborn mice, the tissue had completely regenerated. The problem, though, is that researchers found mice lost the capacity to regenerate cardiac tissue by the time they were seven days old.

The potential implications, the scientists report, is this: "For a brief period after birth, the mammalian heart appears to have the capacity to regenerate." Which means, according to The Guardian, potentially very good things for heart attack sufferers.

"Now that we know that the mammalian heart indeed possesses the potential to regenerate, at least early in life," Eric Olson, one of the study's authors told The Guardian, "we can begin to search for drugs or genes or other things that might reawaken this potential in the adult heart of mice and eventually of humans."

Shared from: The Huffington Post

Whole Grain Fiber Linked to Longer Life

Eating a diet rich in fiber—especially the kind of fiber found in whole grains—reduces the risk of dying at an early age from a range of causes, a new government study suggests.

Fiber’s beneficial effects on heart health have been known for decades, so it wasn’t surprising that eating a lot of fiber was associated with a lower risk of death due to heart attackand heart disease. But fiber intake also appears to lower the risk of dying from respiratory diseases (such as pneumonia and chronic bronchitis) and infectious diseases, the study found.

“The benefits of fiber are broader than what had been anticipated or previously studied,” says Frank Hu, MD, a professor of nutrition and epidemiology at the Harvard School of Public Health in Boston, who co-authored an editorial accompanying the study. Both were published today on the website of the Archives of Internal Medicine.

The source of the fiber appears to be critical. Consuming fiber from whole grains was most strongly linked to a lower risk of dying during the study, while fiber from vegetables and beans appeared to have a minimal impact on death risk. The fiber in fruit seemed to offer no protection at all.The study, which was funded by the National Cancer Institute (NCI), also found a link between fiber consumption and a reduced risk of death from cancer, but only in men.

“We only see significant effects from whole grains,” says the lead author of the study, Yikyung Park, a researcher in the NCI’s nutritional epidemiology branch. “But we don’t know how this fiber works to improve health.”

This unexpected finding suggests that the antioxidants and other nutrients in whole grains—not just the fiber—may be partly responsible for promoting health and long life.

“Is the fiber in whole grains truly different? Or are you getting the benefits from [the other nutrients]?” says David Frid, MD, a cardiologist at the Cleveland Clinic who was not involved in the study. “We don’t know.”

Park and her colleagues analyzed data on more than half a million AARP members between the ages of 50 and 71 who answered survey questions about their eating habits as part of a nine-year study on diet and health.

The participants who reported eating the most fiber—about 30 grams a day for men, and 25 grams a day for women—were 22% less likely to die from any cause during the study than those who consumed the least (about 13 grams and 11 grams for men and women, respectively).

Published at: health.com

Good Conversation Can Boost Brain Power, Study Finds

Friendly discussions with other people can help you solve common life challenges, but conversations that are competitive in tone aren’t helpful, finds a new study.

“This study shows that simply talking to other people, the way you do when you’re making friends, can provide mental benefits,” lead author Oscar Ybarra, a psychologist and researcher at the Institute for Social Research at the University of Michigan, said in a university news release.

In this study of 192 undergraduates, the researchers examined the effect that brief episodes of social contact had on a type of cognition called executive function, which includes working memory, self-monitoring, and the ability to suppress external and internal distractions. These mental processes are essential in dealing with day-to-day problems.

Engaging in a short, 10-minute conversation in which they got to know another person helped boost the participants’ performance on a variety of cognitive tasks. But when the conversations had a competitive tone, the participants showed no improvement on the cognitive tasks.

The study will be published in an upcoming issue of the journal Social Psychological and Personality Science.

“We believe that performance boosts come about because some social interactions induce people to try to read others’ minds and take their perspectives on things,” Ybarra said. “And we also find that when we structure even competitive interactions to have an element of taking the other person’s perspective, or trying to put yourself in the other person’s shoes, there is a boost in executive functioning as a result.”

The findings suggest that having a friendly talk with a colleague before a big test or presentation may prove beneficial, according to the researchers.

More information

The U.S. National Center for Learning Disabilities has more aboutexecutive function.

– Robert Preidt

SOURCE: University of Michigan, news release, Oct. 28, 2010

Last Updated: Nov. 04, 2010

Copyright © 2010 HealthDay. All rights reserved.

Happiness Is a Focused Mind

By Jenifer Goodwin
HealthDay Reporter

If you want to be happy, try to stay focused.

New research shows that when people’s minds drifted from the task or activity at hand, they reported being less happy than when they were fully engaged in whatever they were doing.

The human mind is uniquely capable of wandering — that is, to ponder things that have happened, to anticipate things that will happen, and to plan for things that might happen, explained study author Matthew Killingsworth, a doctoral candidate in psychology at Harvard University. The ability is one of the traits that makes human beings human, he noted.

Yet, cognitive wandering comes at a cost, which is that when people are thinking about something other than what they’re doing, they feel less happy, the researchers discovered.

“Human beings seem to have this unique capacity to focus on the non-present. They have the ability to reflect on the past, plan for the future and imagine things that might never occur,” Killingsworth said. “But at the same time, human beings are clumsy users of this capacity and it tends to decrease, rather than increase, happiness.”

In the study, 2,250 participants were prompted at random times throughout the day using an iPhone Web application. They were asked how they were feeling, what they were doing, if they were thinking about something other than what they were doing and whether whatever they were contemplating was pleasant (say, daydreaming about a vacation), unpleasant (perhaps worrying about a relationship or finances) or neutral in nature.

According to the study, participants spent nearly 47 percent of their waking hours with their mind in a wandering state. “This study shows that our mental lives are pervaded, to a remarkable degree, by the non-present,” Killingsworth said.

That is, with one notable exception. When describing what they were doing, participants could choose from 22 activities, including walking, eating, shopping, watching TV, commuting and working.

The only activity during which people seemed to be quite good at staying on task mentally was while making love. During sex, only 10 percent of people reported wandering thoughts.

Generally, people also reported being the happiest when making love, exercising or conversing. They said they were least happy when resting or sleeping, working or using a home computer.

When it came to what they were thinking about, 42.5 percent thought of pleasant topics, 26.5 percent thought of unpleasant topics, while 31 percent were thinking neutral thoughts.

And while people who were thinking of pleasant things were happier than people thinking of unpleasant things, even those thinking happy thoughts were less happy than people who were fully engaged in whatever they were doing.

The study is published in the Nov. 12 issue of Science.

In some ways, the research provides scientific evidence of what many self-help books and some religious traditions espouse, which is that being in the “here and now” is critical for happiness, Killingsworth said.

Participants were from 83 counties, a wide range of occupations and ranged in age from 18 to 88.

Barbara Becker Holstein, a psychologist and “happiness coach” in Long Branch, N.J., said the findings speak to the importance of doing things that provide a sense of purpose and meaning. Such activities make it easier to stay focused, Holstein explained.

“This research is fabulous and fascinating,” Holstein said. “But long before the research, psychologists and many educators recognized that in order to feel a sense of well-being, you need to feel you have purpose and meaning in life. That means you are containing the mind around certain projects and activities, and are forcing the mind not to be all over the place all day long.”

If you feel your mind starting to head down a “dark tunnel” of worry and anxiety, try to snap yourself out of it by bringing your thoughts back to the present, she said.

“It’s such a natural tendency to go over bad news or things that haven’t worked out, to dramatize the drama we are already experiencing,” she said. “But if we can distract ourselves by getting involved doing something, we get some distance from whatever we were ruminating on and it’s better for us.”

More information

If you’d like to be part of Harvard’s happiness research project, visittrackyourhappiness.org.

SOURCES: Matthew Killingsworth, doctoral candidate, Harvard University, Cambridge, Mass.; Barbara Becker Holstein, Ed.D., psychologist and happiness coach, Long Branch, N.J.; Nov. 12, 2010, Science

Last Updated: Nov. 11, 2010

Copyright © 2010 HealthDay. All rights reserved.

Speaking 2 languages may delay getting Alzheimer's

New studies suggest bilingual ability increases executive control in the brain, which could fight mental disease

Mastering a second language can pump up your brain in ways that seem to delay getting Alzheimer's disease later on, scientists said Friday.

Never learned to habla or parlez? While the new research focuses mostly on the truly long-term bilingual, scientists say even people who tackle a new language later in life stand to gain.

The more proficient you become, the better, but "every little bit helps," said Ellen Bialystok, a psychology professor at York University in Toronto.

Much of the study of bilingualism has centered on babies, as scientists wondered why simply speaking to infants in two languages allows them to learn both in the time it takes most babies to learn one. Their brains seem to become more flexible, better able to multitask. As they grow up, their brains show better "executive control," a system key to higher functioning -- as Bialystok puts it, "the most important part of your mind."

But does that mental juggling while you're young translate into protection against cognitive decline when you're old?

Bialystok studied 450 Alzheimer's patients, all of whom showed the same degree of impairment at the time of diagnosis. Half are bilingual -- they've spoken two languages regularly for most of their lives. The rest are monolingual.

The bilingual patients had Alzheimer's symptoms and were diagnosed between four and five years later than the patients who spoke only one language, she told the annual meeting of the American Association for the Advancement of Science.

Being bilingual does nothing to prevent Alzheimer's disease from striking. But once the disease does begin its silent attack, those years of robust executive control provide a buffer so that symptoms don't become apparent as quickly, Bialystok said.

"They've been able to cope with the disease," she said.

Her work supports an earlier study from other researchers that also found a protective effect.

What is it about being bilingual that enhances that all-important executive control system?

Both languages are essentially turned on all the time, but the brain learns to inhibit the one you don't need, said psychology professor Teresa Bajo of the University of Granada in Spain. That's pretty constant activity.

That's not the only area. University of British Columbia psychologist Janet Werker studies infants exposed to two languages from birth to see why they don't confuse the two, and says bilingual babies learn very early to pay attention better.

Werker tested babies in Spain who were growing up learning both Spanish and Catalan. She showed the babies videos of women speaking languages they'd never heard -- English and French -- but with the sound off. By measuring the tots' attention span, Werker concluded that babies could distinguish between English and French simply by watching the speakers' facial cues. It could have been the different lip shapes.

"It looks like French people are always kissing," she joked, while the English "th" sound evokes a distinctive lip-in-teeth shape.

Whatever the cues, monolingual babies couldn't tell the difference, Werker said Friday at the meeting.

But what if you weren't lucky enough to be raised bilingual? Scientists and educators know that it becomes far harder to learn a new language after puberty.

Partly that's because adults' brains are so bombarded with other demands that we don't give learning a new language the same attention that a young child does, Bialystok said.

At the University of Maryland, scientists are studying how to identify adults who would be good candidates to master a new language, and then what types of training are best. Having a pretty strong executive control system, like the lifelong bilinguals have, is among the good predictive factors, said Amy Weinberg, deputy director of the university's Center for Advanced Study of Language.

But people don't have to master a new language to benefit some, Bialystok said. Exercising your brain throughout life contributes to what's called cognitive reserve, the overall ability to withstand the declines of aging and disease. That's the basis of the use-it-or-lose-it advice from aging experts who also recommend such things as crossword puzzles to keep your brain nimble.

"If you start to learn at 40, 50, 60, you are certainly keeping your brain active," she said.

Published at: Salon

Chocolate's Startling Health Benefits

The food police may find this hard to take, but chocolate has gotten a bad rap. People say it causes acne, that you should eat carob instead, that it's junk food. But these accusations are not only undeserved and inaccurate, they falsely incriminate a delicious food that turns out to have profoundly important healing powers.

There is in fact a growing body of credible scientific evidence that chocolate contains a host of heart-healthy and mood-enhancing phytochemicals, with benefits to both body and mind.

For one, chocolate is a plentiful source of antioxidants. These are substances that reduce the ongoing cellular and arterial damage caused by oxidative reactions.

You may have heard of a type of antioxidants called polyphenols. These are protective chemicals found in plant foods such as red wine and green tea. Chocolate, it turns out, is particularly rich in polyphenols. According to researchers at the University of Texas Southwestern Medical Center in Dallas, the same antioxidant properties found in red wine that protect against heart disease are also found in comparable quantities in chocolate.

How does chocolate help to prevent heart disease? The oxidation of LDL cholesterol is considered a major factor in the promotion of coronary disease. When this waxy substance oxidizes, it tends to stick to artery walls, increasing the risk of a heart attack or stroke. But chocolate to the rescue! The polyphenols in chocolate inhibit oxidation of LDL cholesterol.

And there's more. One of the causes of atherosclerosis is blood platelets clumping together, a process called aggregation. The polyphenols in chocolate inhibit this clumping, reducing the risks of atherosclerosis.

High blood pressure is a well known risk factor for heart disease. It is also one of the most common causes of kidney failure, and a significant contributor to many kinds of dementia and cognitive impairment. Studies have shown that consuming a small bar of dark chocolate daily can reduce blood pressure in people with mild hypertension.

Why are people with risk factors for heart disease sometimes told to take a baby aspirin every day? The reason is that aspirin thins the blood and reduces the likelihood of clots forming (clots play a key role in many heart attacks and strokes). Research performed at the department of nutrition at the University of California, Davis, found that chocolate thins the blood and performs the same anti-clotting activity as aspirin. "Our work supports the concept that the chronic consumption of cocoa may be associated with improved cardiovascular health," said UC Davis researcher Carl Keen.

How much chocolate would you have to eat to obtain these benefits? Less than you might think. According to a study published in the American Journal of Clinical Nutrition, adding only half an ounce of dark chocolate to an average American diet is enough to increase total antioxidant capacity 4 percent, and lessen oxidation of LDL cholesterol.

Why, then, has chocolate gotten such a bum reputation? It's the ingredients we add to it. Nearly all of the calories in a typical chocolate bar are sugar and fat.

As far as fats go, it's the added fats that are the difficulty, not the natural fat (called cocoa butter) found in chocolate. Cocoa butter is high in saturated fat, so many people assume that it's not good for your cardiovascular system. But most of the saturated fat content in cocoa butter is stearic acid, which numerous studies have shown does not raise blood cholesterol levels. In the human body, it acts much like the monounsaturated fat in olive oil.

Milk chocolate, on the other hand, contains added butterfat which can raise blood cholesterol levels. And it has less antioxidants and other beneficial phytochemicals than dark chocolate.

Does chocolate contribute to acne? Milk chocolate has been shown to do so, but I've never heard of any evidence incriminating dark chocolate.

Dark chocolate is also healthier because it has less added sugar. I'm sure you don't need another lecture on the dangers of excess sugar consumption. But if you want to become obese and dramatically raise your odds of developing diabetes, heart disease, cancer and Alzheimer's disease, foods high in sugar (including high fructose corn syrup) are just the ticket.

Are chocolate's benefits limited to the health of the body? Hardly. Chocolate has long been renown for its remarkable effects on human mood. We are now beginning to understand why.

Chocolate is the richest known source of a little-known substance called theobromine, a close chemical relative of caffeine. Theobromine, like caffeine, and also like the asthma drug theophylline, belong to the chemical group known as xanthine alkaloids. Chocolate products contain small amounts of caffeine, but not nearly enough to explain the attractions, fascinations, addictions, and effects of chocolate. The mood enhancement produced by chocolate may be primarily due to theobromine.

Chocolate also contains other substances with mood elevating effects. One is phenethylamine, which triggers the release of pleasurable endorphins and potentates the action of dopamine, a neurochemical associated with sexual arousal and pleasure. Phenethylamine is released in the brain when people become infatuated or fall in love.

Another substance found in chocolate is anandamide (from the Sanskrit word "ananda," which means peaceful bliss). A fatty substance that is naturally produced in the brain, anandamide has been isolated from chocolate by pharmacologists at the Neurosciences Institute in San Diego. It binds to the same receptor sites in the brain as cannabinoids -- the psychoactive constituents in marijuana -- and produces feelings of elation and exhilaration. (If this becomes more widely known, will they make chocolate illegal?)

If that weren't enough, chocolate also boosts brain levels of serotonin. Women typically have lower serotonin levels during PMS and menstruation, which may be one reason women typically experience stronger cravings for chocolate at these times in their cycles. People suffering from depression so characteristically have lower serotonin levels that an entire class of anti-depressive medications called serotonin uptake inhibitors (including Prozac, Paxil, and Zooloft) have been developed that raise brain levels of serotonin.

Since I am known as an advocate of healthy eating, I'm often asked about my food indulgences. One of my favorite desserts is a piece of dark organic chocolate, along with a glass of a fine red wine.

I do have a policy, though, to eat only organic and/or fair trade chocolate. This is because of what I have learned about child slavery in the cocoa trade.

May your life be full of healthy pleasures.

John Robbins is the author of many bestsellers including "The Food Revolution: How Your Diet Can Help Save Your Life and Our World," the classic "Diet For A New America," and "The New Good Life: Living Better Than Ever in an Age of Less." He is the recipient of the Rachel Carson Award, the Albert Schweitzer Humanitarian Award, the Peace Abbey's Courage of Conscience Award, and Green America's Lifetime Achievement Award. To learn more about his work, visitwww.johnrobbins.info

Published at: The Huffington Post